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It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see Adverse Reactions ( 6.1, olanzapine 5mg velotab 6.2)].
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In healthy volunteers, olanzapine 100mg 1g relative bioavailability of valacyclovir compared to that of acyclovir was 3.3 to 5 times greater; acyclovir bioavailability is 54% when administered as valacyclovir compared to 10—20% when administered as acyclovir itself. Following a single intravenous infusion of 500 mg metronidazole, the mean AUC 24 of metronidazole was higher by 114% in patients with severe (Child-Pugh C) hepatic impairment, and by 54% and 53% in patients with mild (Child-Pugh A), and moderate (Child-Pugh B) hepatic impairment, respectively, compared to healthy control subjects.
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In infants aged 1 month to less than 3 months, olanzapine odt 5mg mean acyclovir exposures resulting from a 25─mg/kg dose were higher (C max: ↑30%, AUC: ↑60%) than acyclovir exposures following a 1─gram dose of valacyclovir in adults.
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